About Picato®

Short, 2- or 3-day dosing with Picato®*

*In studies with Picato®, results were measured after 8 weeks.

Picato® for body, arms, or legs, with 2-day dosing Picato® for face or scalp, with 3-day dosing

Review the full Instructions for Use.

One tube will cover a continuous area of approximately 2x2 inches or 25 cm2.


Important Safety Information

Reports of hypersensitivity reactions (anaphylaxis and allergic contact dermatitis) and herpes zoster (shingles) have been received during post approval use of Picato®.

See additional Important Safety Information.

Picato® has the fastest dosing of any AK topical*

Comparison dosing chart for Picato® vs other topicals for actinic keratosis Comparison dosing chart for Picato® vs other topicals for actinic keratosis

Indications, efficacy, and safety of the products listed above may vary. This chart is not intended to compare the safety or efficacy of products.

*In studies with Picato®, results were measured at Week 8 (Day 57).


Ask a dermatologist about AK treatment options and which is best for you

Getting started: how to apply Picato® gel

Once-daily dosing in 5 steps

1 | Open

a new tube each time you use Picato® gel. Remove cap from tube just before use.

2 | Squeeze

the gel from the tube onto your fingertip. Only use enough gel needed to cover the affected area (one tube covers a continuous skin area of up to 2 inches by 2 inches), as directed by your healthcare provider.

3 | Spread

the gel evenly over only the skin area to be treated.

4 | Wash

your hands right away after applying gel. If treating your hands, wash only the fingertip you used to apply the gel. Safely throw away the tube after single use.

5 | Dry

treated area for 15 minutes.

Important:

  • One tube will cover a continuous area of about 2x2 inches
  • Keep out of the reach of children
  • Avoid touching the treatment area or doing activities that cause a lot of sweating for 6 hours after applying Picato® gel
  • Do not use Picato® gel in, around, or near your eyes, mouth, lips, or vagina
  • Do not apply right after taking a shower or less than 2 hours before bedtime
  • Due to the nature of AK, excessive or prolonged exposure to UV light should always be avoided
  • Do not use Picato® on an area of skin larger or for a longer period than instructed in the drug label

Important Safety Information

Eye problems, including severe eye pain, swelling or drooping of your eyelids, corneal burn, redness, swelling and irritation inside the eye, or swelling around your eyes can happen if Picato® gel gets in your eyes.

See additional Important Safety Information.

Remember: Keep Picato® cool to keep it effective

  • Picato® must be refrigerated. Store Picato® at temperatures between 36°F to 46°F (2°C to 8°C)
  • Do not freeze
  • Do not leave Picato® on a kitchen counter, in a car, or any other area where the temperature could rise above 46°F. This could reduce its effectiveness

Indication

Picato® (ingenol mebutate) gel, 0.015%, 0.05% is prescription medicine used on the skin to treat actinic keratosis.

Important Safety Information

Do not use Picato® gel if you are allergic to ingenol mebutate or any of the ingredients in Picato® gel.

Eye problems, including severe eye pain, swelling or drooping of your eyelids, corneal burn, redness, swelling and irritation inside the eye, or swelling around your eyes can happen if Picato® gel gets in your eyes. To avoid getting any of the Picato® into or around the eyes, it is important that you wash your hands well with soap and water after applying Picato® gel and be careful to keep Picato® gel on the treated area from coming into contact with your eyes. If you accidentally get Picato® gel in your eyes, flush them with large amounts of water and get medical care as soon as possible.

There have been reports of serious allergic reactions (hives, itching, flushing and swelling of the lips or tongue, trouble breathing or wheezing, chest tightness and dizziness or passing out) in patients using Picato®. The frequency of these events or their relationship, if any, to treatment with Picato® is unknown. If you experience any such symptoms, discontinue Picato® immediately and seek emergency medical help.

For use on the skin only. Picato® can be applied to a contiguous skin area of approximately 25 cm2 (5 cm x 5 cm). Do not use Picato® in, around, or near your eyes, mouth, lips, or vagina.

Reports of hypersensitivity reactions (anaphylaxis and allergic contact dermatitis) and herpes zoster (shingles) have been received during post approval use of Picato®.

Severe skin reactions in the treated areas on the face/scalp and body/arms/legs, including redness, flaking or scaling, crusting, swelling, blisters, pus, ulcers or breakdown of your skin can happen after applying Picato®. You may also see changes in your skin color (pigmentation changes) and scarring where Picato® gel is applied. You should not use Picato® gel until your skin has healed from other treatments or surgeries. The most common side effects with Picato® gel on the face and scalp (≥2%) include skin reactions in the treatment area (94%), pain at the treatment area (15%), itching at the treatment area (8%), infection at the treatment area (3%), swelling around your eyelids (3%), and headache (2%). The most common side effects with Picato® gel on the body, arms and legs (≥2%) include skin reactions in the treatment area (92%), itching at the treatment area (8%), skin irritation at the treatment area (4%), nose and throat irritation (2%), and pain at the treatment area (2%).

Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if Picato® gel can harm your unborn baby.

It is also not known if Picato® is safe and effective for the treatment of actinic keratosis in children less than 18 years of age.

You may report side effects to the FDA at 1-800-FDA-1088 or visit www.fda.gov/Safety/MedWatch.

You may also report side effects to LEO Pharma Inc. at 1-877-494-4536, option 1, or email to usdrugsafety@leo-pharma.com.

Please see Picato® Full Prescribing Information.

Eligibility criteria: 1. This card is good for use only with a valid prescription for Picato®. 2. This card is valid for up to 12 ‭prescription fills per calendar year for Picato®. 3. For patients with commercial health insurance, this card may reduce out-of-pocket expenses. 4. Offer good only in the USA at participating retail pharmacies. 5. Original card must be presented to the pharmacist ‭at the time the prescription is filled. Not valid if reproduced. 6. Only one card per patient. 7. The selling, purchasing, trading, or counterfeiting of this card is prohibited by law. 8. Card is not transferable. 9. You must be 18 years of age or older to use this card with your Picato® prescription. 10. This card is not health ‭insurance. 11. You are responsible for the use of this card and ‭for complying with reporting obligations, if any, of your insurance plan. 12. You may not use this card if you are enrolled in any state or federal healthcare program, including Medicaid, Medicare ‭(including Medicare Part D), Medigap, VA, DoD, TRICARE or Chip, unless not eligible for drug coverage in whole or in part. 13. Offer ‭void where prohibited by law, taxed, or restricted. 14. Not valid ‭in combination with any other offers, discounts, or programs. 15. Card has no cash value. 16. LEO Pharma Inc. reserves the right to rescind, revoke, or amend this offer without notice. ‭ 17. You understand and agree to the terms and conditions as set forth above. Full details of the LEO Franchise Card Program may be obtained by calling 1-855-820-9627 (Monday - Friday, 8:00 ‭AM‭-8:00 ‭PM ET) or visiting www.activatethecard.com/LEO.

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